CDKN2A/p19ARF Monoclonal Antibody
- SKU:
- CAB24653
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | CDKN2A/p19ARF Monoclonal Antibody |
| Product Code: | CAB24653 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC62845 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A20 |
| Cellular Location: | Nucleus, nucleoplasm |
Enables MDM2/MDM4 family protein binding activity; enzyme inhibitor activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of cellular protein metabolic process; negative regulation of mammary gland epithelial cell proliferation; and positive regulation of apoptotic process involved in mammary gland involution. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including bone marrow; central nervous system; dorsal root ganglion; eye; and testis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A).
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse p19ARF (NP_034007.1). |
| Sequence: | MGRRF LVTVR IQRAG RPLQE RVFLV KFVRS RRPRT ASCAL AFVNM LLRLE RILRR GPHRN PGPGD DDGQR SRSSS SAQLR CRFEL RGPHY LLPPG ARRSA |
| Synonyms: | Arf, p16, MTS1, Pctr1, p19ARF, p16INK4a, p19, ARF-INK4a, INK4a-ARF, Ink4a/Arf, p16(INK4a) |
| Calculated MW: | 19KDa |
| Observed MW: | 21kDa |
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