CDKL5 Antibody (PACO61911)
- SKU:
- PACO61911
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CDKL5 Antibody (PACO61911) |
| Antibody SKU: | PACO61911 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human Cyclin-dependent kinase-like 5 protein (790-921AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, PC3 whole cell lysate, 293 whole cell lysate, K562 whole cell lysate, HepG2 whole cell lysate, Rat spleen tissue. All lanes: CDKL5 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 116, 108 kDa. Observed band size: 116 kDa. |
| Background: | Mediates phosphorylation of MECP2. |
| Synonyms: | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9), CDKL5, STK9 |
| UniProt Protein Function: | CDKL5: a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.11.22; Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDKL familyChromosomal Location of Human Ortholog: Xp22Cellular Component: cytoplasm; dendrite cytoplasm; nucleoplasm; nucleusMolecular Function: ATP binding; kinase activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase bindingBiological Process: neuron migration; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of GTPase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite developmentDisease: Angelman Syndrome; Epileptic Encephalopathy, Early Infantile, 2 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76039 |
| NCBI GenInfo Identifier: | 6175070 |
| NCBI Gene ID: | 6792 |
| NCBI Accession: | O76039.1 |
| UniProt Secondary Accession: | O76039,Q14198, Q5H985, Q8IYC7, Q9UJL6, G9B9X4 |
| UniProt Related Accession: | O76039 |
| Molecular Weight: | 107,519 Da |
| NCBI Full Name: | Cyclin-dependent kinase-like 5 |
| NCBI Synonym Full Names: | cyclin dependent kinase like 5 |
| NCBI Official Symbol: | CDKL5 |
| NCBI Official Synonym Symbols: | ISSX; STK9; EIEE2; CFAP247 |
| NCBI Protein Information: | cyclin-dependent kinase-like 5 |
| UniProt Protein Name: | Cyclin-dependent kinase-like 5 |
| UniProt Synonym Protein Names: | Serine/threonine-protein kinase 9 |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDKL5 |
| UniProt Entry Name: | CDKL5_HUMAN |
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