CDK5 Polyclonal Antibody
- SKU:
- CAB2689
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | CDK5 Polyclonal Antibody |
| Product Code: | CAB2689 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, NIH/3T3 |
| Cellular Location: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Nucleus, Perikaryon, Peripheral membrane protein, growth cone, lamellipodium, postsynaptic cell membrane, postsynaptic density, synapse |
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CDK5 (NP_004926.1). |
| Sequence: | MQKYE KLEKI GEGTY GTVFK AKNRE THEIV ALKRV RLDDD DEGVP SSALR EICLL KELKH KNIVR LHDVL HSDKK LTLVF EFCDQ DLKKY FDSCN GDLDP EIVKS FLFQL LKGLG FCHSR NVLHR DLKPQ NLLIN RNGEL KLADF GLARA FGIPV RCYSA EVVTL WYRPP DVLFG AKLYS TSIDM WSAGC IFAEL ANAGR PLFPG NDVDD QLKRI FRLLG TPTEE QWPSM TKLPD YKPYP MYPAT TSLVN VVPKL NATGR DLLQN LLKCN PVQRI SAEEA LQHPY FSDFC PP |
| Synonyms: | LIS7, PSSALRE |
| Calculated MW: | 33kDa |
| Observed MW: | 33kDa |
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