CDK4 Polyclonal Antibody
- SKU:
- CAB21317
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
- Applications:
- IF
Description
| Product Name: | CDK4 Polyclonal Antibody |
| Product Code: | CAB21317 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC-P, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:100, IP 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, 293T |
| Cellular Location: | Cytoplasm, Membrane, Nucleus |
| Customer Validation: | WB(Homo sapiens) |
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-303 of human CDK4 (NP_000066.1). |
| Sequence: | VGCIF AEMFR RKPLF CGNSE ADQLG KIFDL IGLPP EDDWP RDVSL PRGAF PPRGP RPVQS VVPEM EESGA QLLLE MLTFN PHKRI SAFRA LQHSY LHKDE GNPE |
| Synonyms: | CMM3, PSK-J3 |
| Calculated MW: | 34kDa |
| Observed MW: | 35kDa |
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