CDK3 Antibody (PACO61514)
- SKU:
- PACO61514
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CDK3 Antibody (PACO61514) |
| Antibody SKU: | PACO61514 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cyclin-dependent kinase 3 protein (220-297AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61514 diluted at 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
| Synonyms: | Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3 |
| UniProt Protein Function: | CDK3: a protein kinase of the CDK family. May be involved in cell cycle control. Can phosphorylate histone H1. |
| UniProt Protein Details: | Protein type:Kinase, protein; Cell cycle regulation; Protein kinase, CMGC; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily Chromosomal Location of Human Ortholog: 17q25.1 Biological Process: cell proliferation; G0 to G1 transition; G1/S transition of mitotic cell cycle; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q00526 |
| NCBI GenInfo Identifier: | 231726 |
| NCBI Gene ID: | 1018 |
| NCBI Accession: | Q00526.1 |
| UniProt Related Accession: | Q00526 |
| Molecular Weight: | 35,046 Da |
| NCBI Full Name: | Cyclin-dependent kinase 3 |
| NCBI Synonym Full Names: | cyclin dependent kinase 3 |
| NCBI Official Symbol: | CDK3 |
| NCBI Protein Information: | cyclin-dependent kinase 3 |
| UniProt Protein Name: | Cyclin-dependent kinase 3 |
| UniProt Synonym Protein Names: | Cell division protein kinase 3 |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDK3 |
| UniProt Entry Name: | CDK3_HUMAN |
| Antibodies | ELISA Kits |
| CDK3 Antibody (PACO08337) | Human CDKN3 ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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