CDK12 Monoclonal Antibody (CAB22474)
- SKU:
- CAB22474
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | CDK12 Monoclonal Antibody |
| Product Code: | CAB22474 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53277 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus, Nucleus speckle |
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-516 of human CDK12 (NP_057591.2). |
| Sequence: | SKGSP VFLPR KENSS VEAKD SGLES KKLPR SVKLE KSAPD TELVN VTHLN TEVKN SSDTG KVKLD ENSEK HLVKD LKAQG TRDSK PIALK EEIVT PK |
| Synonyms: | CRK7, CRKR, CRKRS |
| Calculated MW: | 164kDa |
| Observed MW: | Refer to figures |
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