CDC42EP5 Antibody (PACO22247)
- SKU:
- PACO22247
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CDC42EP5 Antibody (PACO22247) |
| Antibody SKU: | PACO22247 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from N-terminal of human BORG3. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using BORG3 antibody. |
| Background: | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 By similarity. |
| Synonyms: | binder of Rho GTPases 3; Borg3; Cdc42 effector 5; CEP5; |
| UniProt Protein Function: | CDC42EP5: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. Belongs to the BORG/CEP family.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: cytoskeleton; membrane; cytoplasm; plasma membrane; endomembrane systemMolecular Function: GTP-Rho bindingBiological Process: regulation of cell shape; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; JNK cascade; Rho protein signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6NZY7 |
| NCBI GenInfo Identifier: | 30089966 |
| NCBI Gene ID: | 148170 |
| NCBI Accession: | NP_659494.2 |
| UniProt Secondary Accession: | Q6NZY7,Q8TB51, B0VJZ2 |
| UniProt Related Accession: | Q6NZY7 |
| Molecular Weight: | 15,207 Da |
| NCBI Full Name: | cdc42 effector protein 5 |
| NCBI Synonym Full Names: | CDC42 effector protein (Rho GTPase binding) 5 |
| NCBI Official Symbol: | CDC42EP5 |
| NCBI Official Synonym Symbols: | CEP5; Borg3 |
| NCBI Protein Information: | cdc42 effector protein 5; 1700027J19Rik; 2010007O02Rik; binder of Rho GTPases 3 |
| UniProt Protein Name: | Cdc42 effector protein 5 |
| UniProt Synonym Protein Names: | Binder of Rho GTPases 3 |
| Protein Family: | |
| UniProt Gene Name: | CDC42EP5 |
| UniProt Entry Name: | BORG3_HUMAN |
| Antibodies |
| CDC42EP5 Antibody (PACO00570) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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