CDC42EP4 Antibody (PACO22246)
- SKU:
- PACO22246
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CDC42EP4 Antibody (PACO22246) |
| Antibody SKU: | PACO22246 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human BORG4. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using BORG4 antibody. |
| Background: | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Synonyms: | binder of Rho GTPases 4; BORG4; CDC42 effector protein (Rho GTPase binding) 4; Cdc42 effector protein 4; CEP4 |
| UniProt Protein Function: | CDC42EP4: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. Belongs to the BORG/CEP family.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 17q24-q25Cellular Component: microtubule cytoskeleton; cytoplasm; plasma membrane; endomembrane system; actin cytoskeletonMolecular Function: GTP-Rho bindingBiological Process: regulation of cell shape; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; Rho protein signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H3Q1 |
| NCBI GenInfo Identifier: | 21362403 |
| NCBI Gene ID: | 23580 |
| NCBI Accession: | Q9H3Q1.1 |
| UniProt Secondary Accession: | Q9H3Q1,O95828, Q96FT3, B3KUS7 |
| UniProt Related Accession: | Q9H3Q1 |
| Molecular Weight: | 38kd |
| NCBI Full Name: | Cdc42 effector protein 4 |
| NCBI Synonym Full Names: | CDC42 effector protein (Rho GTPase binding) 4 |
| NCBI Official Symbol: | CDC42EP4 |
| NCBI Official Synonym Symbols: | CEP4; BORG4; KAIA1777 |
| NCBI Protein Information: | cdc42 effector protein 4; binder of Rho GTPases 4 |
| UniProt Protein Name: | Cdc42 effector protein 4 |
| UniProt Synonym Protein Names: | Binder of Rho GTPases 4 |
| Protein Family: | Cdc42 effector protein |
| UniProt Gene Name: | CDC42EP4 |
| UniProt Entry Name: | BORG4_HUMAN |
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