CDC42EP2 Antibody (PACO22244)
- SKU:
- PACO22244
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CDC42EP2 Antibody (PACO22244) |
| Antibody SKU: | PACO22244 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human BORG1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from K562 cells, using BORG1 antibody. |
| Background: | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. |
| Synonyms: | Cdc42 effector protein 2; Binder of Rho GTPases 1; |
| UniProt Protein Function: | CDC42EP2: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. Belongs to the BORG/CEP family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cytoplasm; cytosol; membrane; microtubule cytoskeleton; plasma membrane Molecular Function:GTP-Rho binding; GTPase activator activity; protein binding Biological Process: actin cytoskeleton organization and biogenesis; positive regulation of actin filament polymerization; positive regulation of protein complex assembly; positive regulation of pseudopodium formation; regulation of cell shape; Rho protein signal transduction |
| NCBI Summary: | CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011] |
| UniProt Code: | O14613 |
| NCBI GenInfo Identifier: | 71152337 |
| NCBI Gene ID: | 10435 |
| NCBI Accession: | O14613.1 |
| UniProt Secondary Accession: | O14613,Q9UNS0, B2RD85, |
| UniProt Related Accession: | O14613 |
| Molecular Weight: | 22,484 Da |
| NCBI Full Name: | Cdc42 effector protein 2 |
| NCBI Synonym Full Names: | CDC42 effector protein 2 |
| NCBI Official Symbol: | CDC42EP2 |
| NCBI Official Synonym Symbols: | CEP2; BORG1 |
| NCBI Protein Information: | cdc42 effector protein 2 |
| UniProt Protein Name: | Cdc42 effector protein 2 |
| UniProt Synonym Protein Names: | Binder of Rho GTPases 1 |
| Protein Family: | Cdc42 effector protein |
| UniProt Gene Name: | CDC42EP2 |
| UniProt Entry Name: | BORG1_HUMAN |
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