CDC26 Antibody (PACO38334)
- SKU:
- PACO38334
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CDC26 Antibody (PACO38334) |
| Antibody SKU: | PACO38334 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Anaphase-promoting complex subunit CDC26 protein (1-85AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO38334 at dilution of 1:100. |
| Background: | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. |
| Synonyms: | Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog), CDC26, ANAPC12 C9orf17 |
| UniProt Protein Function: | CDC26: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. Belongs to the CDC26 family.Chromosomal Location of Human Ortholog: 9q32Cellular Component: nucleoplasm; anaphase-promoting complex; cytosolMolecular Function: protein bindingBiological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NHZ8 |
| NCBI GenInfo Identifier: | 21281671 |
| NCBI Gene ID: | 246184 |
| NCBI Accession: | NP_644815.1 |
| UniProt Secondary Accession: | Q8NHZ8 |
| UniProt Related Accession: | Q8NHZ8 |
| Molecular Weight: | 9,777 Da |
| NCBI Full Name: | anaphase-promoting complex subunit CDC26 |
| NCBI Synonym Full Names: | cell division cycle 26 |
| NCBI Official Symbol: | CDC26 |
| NCBI Official Synonym Symbols: | APC12; ANAPC12; C9orf17 |
| NCBI Protein Information: | anaphase-promoting complex subunit CDC26; cell division cycle 26 homolog; anaphase-promoting complex subunit 12; cell division cycle protein 26 homolog; CDC26 subunit of anaphase promoting complex |
| UniProt Protein Name: | Anaphase-promoting complex subunit CDC26 |
| UniProt Synonym Protein Names: | Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homolog |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | CDC26 |
| UniProt Entry Name: | CDC26_HUMAN |
Related Products
HS3ST3B1 Antibody
Overview Product Name:HS3ST3B1 AntibodyProduct Code:PACO64781Size:50µLTarget Names:HS3ST3B1Species Reactivity:Human<
hns Antibody
Overview Product Name:hns AntibodyProduct Code:PACO64777Size:50µLTarget Names:hnsSpecies Reactivity:Escherichia coli
Avpr1b Antibody
Overview Product Name:Avpr1b AntibodyProduct Code:PACO64609Size:50µLTarget Names:Avpr1bSpecies Reactivity:RatHos