Description
system_update_altDatasheet
| Product Name: | CD99 monoclonal antibody |
| Product Code: | AGIM0206 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | HI156 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG2a |
| Host Species: | Mouse |
| Storage: | Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P14209 |
| Background: | CD99 is a ubiquitous transmembrane type I sialoglycoprotein of a unique and poorly characterized protein family. CD99 is heavily O-glycosylated and was described as a T cell costimulator and strong activator of integrin-mediated actin cytoskeleton assembly, promoting cell adhesion and homotypic aggregation, immediate arrest on an inflamed vascular endothelium, and cell migration through it. Ligation of CD99 under some conditions can lead to apoptosis. Originally CD99 was described as a human thymus leukemia antigen, an Ewing??s sarcoma-specific membrane marker, and an adhesion molecule involved in spontaneous rosette formation of T cells with erythrocytes. |
| UniProt Protein Function: | Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes. |
| NCBI Summary: | The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P14209 |
| NCBI GenInfo Identifier: | 119049 |
| NCBI Gene ID: | 4267 |
| NCBI Accession: | P14209.1 |
| UniProt Secondary Accession: | P14209,O00518, Q6ICV7, A6NIW1, |
| UniProt Related Accession: | P14209 |
| Molecular Weight: | 17,128 Da |
| NCBI Full Name: | CD99 antigen |
| NCBI Synonym Full Names: | CD99 molecule (Xg blood group) |
| NCBI Official Symbol: | CD99 |
| NCBI Official Synonym Symbols: | MIC2; HBA71; MIC2X; MIC2Y; MSK5X |
| NCBI Protein Information: | CD99 antigen |
| UniProt Protein Name: | CD99 antigen |
| UniProt Synonym Protein Names: | 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; CD_antigen: CD99 |
| Protein Family: | CD99 antigen |
| UniProt Gene Name: | CD99 |
