Name: CD97 monoclonal antibody (AGIM0065)
SKU: AGIM0065
Availability: OutOfStock

CD97 monoclonal antibody (AGIM0065)

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SKU:

AGIM0065

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

MEM-180

Conjugation:

Unconjugated

Applications:

Description
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Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Store at 4°C. For long-term storage aliquot and sto re at -20°C. Avoid freeze/thaw cycles.
Uniprot:	P48960
Background:	CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.

UniProt Protein Function:	CD97: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: focal adhesion; integral to plasma membrane; membrane; plasma membrane Molecular Function:protein binding; transmembrane receptor activity Biological Process: cell motility; cell-cell signaling; immune response; inflammatory response
NCBI Summary:	This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
UniProt Code:	P48960
NCBI GenInfo Identifier:	90110013
NCBI Gene ID:	976
NCBI Accession:	P48960.4
UniProt Secondary Accession:	P48960,O00718, O76101, Q8NG72, Q8TBQ7, A8K7Z4, B2RBJ9
UniProt Related Accession:	P48960
Molecular Weight:	86,628 Da
NCBI Full Name:	CD97 antigen
NCBI Synonym Full Names:	adhesion G protein-coupled receptor E5
NCBI Official Symbol:	ADGRE5
NCBI Official Synonym Symbols:	CD97; TM7LN1
NCBI Protein Information:	CD97 antigen
UniProt Protein Name:	CD97 antigen
UniProt Synonym Protein Names:	Leukocyte antigen CD97; CD_antigen: CD97
Protein Family:	CD97 antigen
UniProt Gene Name:	CD97
UniProt Entry Name:	CD97_HUMAN