CD90 (Thy 1.1) monoclonal antibody (PE) (AGIM0252)
- SKU:
- AGIM0252
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- MRC OX-7
- Conjugation:
- PE
- Applications:
- FC
Description
| Product Name: | CD90 (Thy 1.1) monoclonal antibody (PE) |
| Product Code: | AGIM0252 |
| Size: | 500 µL |
| Reactivity: | Mouse |
| Clone: | MRC OX-7 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P04216 |
| Background: | CD90 (Thy-1) is an 18-35 kDa GPI-anchored plasma membrane glycoprotein expressed in many cell types, such as in hematopoietic cells and neurons, connective tissues, various fibroblast and stromal cell lines, tumor endothelial cell lines and other. In the mouse, CD90 is expressed mainly on thymocytes and peripheral T lymphocytes. It is involved in T cell activation, cellular adhesion, proliferation and migration, neurite outgrowth, wound healing, apoptosis, and fibrosis. CD90 participates in multiple signaling cascades and its effects are tissue- and cell type-specific. It often functions as an important regulator of cell-cell and cell-matrix interactions. |
| UniProt Protein Function: | THY1: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: anchored to external side of plasma membrane; focal adhesion; growth cone; integral to plasma membrane; endoplasmic reticulum; dendrite; apical plasma membrane; plasma membrane; cytosol; lipid raft; external side of plasma membrane Molecular Function:integrin binding; protein binding; protein kinase binding Biological Process: focal adhesion formation; negative regulation of T cell receptor signaling pathway; cytoskeleton organization and biogenesis; T cell receptor signaling pathway; cell-cell adhesion; retinal cone cell development; negative regulation of protein kinase activity; negative regulation of axonogenesis; positive regulation of T cell activation; angiogenesis; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of cell migration; positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P04216 |
| NCBI GenInfo Identifier: | 20455514 |
| NCBI Gene ID: | 7070 |
| NCBI Accession: | P04216.2 |
| UniProt Secondary Accession: | P04216,Q16008, Q9NSP1, |
| UniProt Related Accession: | P04216 |
| Molecular Weight: | 17,935 Da |
| NCBI Full Name: | Thy-1 membrane glycoprotein |
| NCBI Synonym Full Names: | Thy-1 cell surface antigen |
| NCBI Official Symbol: | THY1 |
| NCBI Official Synonym Symbols: | CD90 |
| NCBI Protein Information: | thy-1 membrane glycoprotein; CDw90; thy-1 antigen; Thy-1 T-cell antigen |
| UniProt Protein Name: | Thy-1 membrane glycoprotein |
| UniProt Synonym Protein Names: | CDw90; Thy-1 antigen; CD_antigen: CD90 |
| Protein Family: | Thy-1 membrane glycoprotein |
| UniProt Gene Name: | THY1 |
| UniProt Entry Name: | THY1_HUMAN |
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