CD81 monoclonal antibody (AGIM0063)
- SKU:
- AGIM0063
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- M38
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD81 monoclonal antibody |
| Product Code: | AGIM0063 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | M38 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P60033 |
| Background: | CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. |
| UniProt Protein Function: | May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P60033 |
| NCBI GenInfo Identifier: | 38503376 |
| NCBI Gene ID: | 975 |
| NCBI Accession: | P60033.1 |
| UniProt Related Accession: | P60033 |
| Molecular Weight: | |
| NCBI Full Name: | CD81 antigen |
| NCBI Synonym Full Names: | CD81 molecule |
| NCBI Official Symbol: | CD81 |
| NCBI Official Synonym Symbols: | S5.7; CVID6; TAPA1; TSPAN28 |
| NCBI Protein Information: | CD81 antigen |
| UniProt Protein Name: | CD81 antigen |
| UniProt Synonym Protein Names: | 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81 |
| Protein Family: | CD81 antigen |
| UniProt Gene Name: | CD81 |
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