CD80 monoclonal antibody (AGIM0059)
- SKU:
- AGIM0059
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- MEM-233
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD80 monoclonal antibody |
| Product Code: | AGIM0059 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | MEM-233 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P33681 |
| Background: | CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigenpresenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response. |
| UniProt Protein Function: | Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. |
| NCBI Summary: | The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P33681 |
| NCBI GenInfo Identifier: | 461606 |
| NCBI Gene ID: | 941 |
| NCBI Accession: | P33681.1 |
| UniProt Secondary Accession: | P33681,Q5DTA9, Q5DTB0, |
| UniProt Related Accession: | P33681 |
| Molecular Weight: | 18,761 Da |
| NCBI Full Name: | T-lymphocyte activation antigen CD80 |
| NCBI Synonym Full Names: | CD80 molecule |
| NCBI Official Symbol: | CD80 |
| NCBI Official Synonym Symbols: | B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1 |
| NCBI Protein Information: | T-lymphocyte activation antigen CD80 |
| UniProt Protein Name: | T-lymphocyte activation antigen CD80 |
| UniProt Synonym Protein Names: | Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80 |
| Protein Family: | T-lymphocyte activation antigen |
| UniProt Gene Name: | CD80 |
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