Description
system_update_alt Datasheet
Product Name: | CD8 Biotin Antibody |
Product Sku: | CPAB0365 |
Size: | 500μg |
Host Species: | Rat |
Immunogen: | Purified Mouse LN T cells. |
Clone: | NYRmCD8. |
Reactivity: | Mouse |
Applications: | Western Blot, Immunohistochemistry |
Purification Method: | Ion Exchange Column. |
Isotype: | IgM |
Background: | CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains bind to class-I MHC molecules alpha-3 domains. |
Synonyms: | CD8, MAL, p32. |
Storage Buffer: | Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |