CD8 Biotin Monoclonal Antibody [NYRmCD8] (CPAB0365)

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SKU:
CPAB0365
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgM
Clone:
NYRmCD8
Applications:
WB
Applications:
IHC

Description

system_update_alt Datasheet
Product Name:CD8 Biotin Antibody
Product Sku:CPAB0365
Size:500μg
Host Species:Rat
Immunogen:Purified Mouse LN T cells.
Clone:NYRmCD8.
Reactivity:Mouse
Applications:Western Blot, Immunohistochemistry
Purification Method:Ion Exchange Column.
Isotype:IgM
Background:CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains bind to class-I MHC molecules alpha-3 domains.
Synonyms:CD8, MAL, p32.
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
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