CD8 Anti-Human [hCD8] (CPAB0305)

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SKU:
CPAB0305
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG

Description

system_update_alt Datasheet
Product Name:CD8 Anti-Human
Product Sku:CPAB0305
Size:500μg
Host Species:Mouse
Immunogen:Purified human PBL CD8+ T cells.
Clone:hCD8.
Reactivity:Human
Applications:
Purification Method:Ion exchange column.
Isotype:IgG2a
Background:CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains binds to class-I MHC molecules alpha-3 domains.
Synonyms:CD8, MAL, p32.
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
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