Name: Cd74 Antibody (PACO25624)
SKU: PACO25624
Availability: OutOfStock

Antibody Name:	Cd74 Antibody (PACO25624)
Antibody SKU:	PACO25624
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:	Mouse
Immunogen:	Recombinant Mouse H-2 class II histocompatibility antigen γ chain protein (56-279AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western Blot
Positive WB detected in: Mouse brain tissue
All lanes: Cd74 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 32, 25 kDa
Observed band size: 32 kDa
.

Background:	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/β heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.
Synonyms:	H-2 class II histocompatibility antigen γ chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74), Cd74, Ii

UniProt Protein Function:	CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Endoplasmic reticulum; Receptor, cytokineCellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; integral to plasma membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuoleMolecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; protein bindingBiological Process: activation of MAPK activity; adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immune response; immune system process; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of adaptive immune response; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of innate immune response; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P04441
NCBI GenInfo Identifier:	110624770
NCBI Gene ID:	16149
NCBI Accession:	NP_001036070.1
UniProt Secondary Accession:	P04441,O19452
UniProt Related Accession:	P04441
Molecular Weight:	29.4 kDa
NCBI Full Name:	H-2 class II histocompatibility antigen gamma chain isoform 1
NCBI Synonym Full Names:	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
NCBI Official Symbol:	Cd74
NCBI Official Synonym Symbols:	Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
NCBI Protein Information:	H-2 class II histocompatibility antigen gamma chain
UniProt Protein Name:	H-2 class II histocompatibility antigen gamma chain
UniProt Synonym Protein Names:	Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain; CD_antigen: CD74
Protein Family:	H-2 class II histocompatibility antigen
UniProt Gene Name:	Cd74
UniProt Entry Name:	HG2A_MOUSE