CD71 monoclonal antibody (FITC) (AGIM0287)

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SKU:
AGIM0287
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Rat
Host Species:
Mouse
Isotype:
IgG2a
Clone:
MRC OX-26
Conjugation:
FITC
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD71 monoclonal antibody (FITC)
Product Code:AGIM0287
Size:500 µL
Reactivity:Rat
Clone:MRC OX-26
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P02786
UniProt Protein Function:TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
UniProt Protein Details:

Protein type:Receptor, misc.; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome

Molecular Function:double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity

Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport

NCBI Summary:This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
UniProt Code:P02786
NCBI GenInfo Identifier:108935939
NCBI Gene ID:7037
NCBI Accession:P02786.2
UniProt Secondary Accession:P02786,Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21 D3DXB0,
UniProt Related Accession:P02786
Molecular Weight:84,871 Da
NCBI Full Name:Transferrin receptor protein 1
NCBI Synonym Full Names:transferrin receptor
NCBI Official Symbol:TFRC  
NCBI Official Synonym Symbols:T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46  
NCBI Protein Information:transferrin receptor protein 1
UniProt Protein Name:Transferrin receptor protein 1
UniProt Synonym Protein Names:T9; p90; CD_antigen: CD71
Protein Family:Transferrin receptor protein
UniProt Gene Name:TFRC  
UniProt Entry Name:TFR1_HUMAN
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