CD68 Monoclonal Antibody (CAB22329)
- SKU:
- CAB22329
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | CD68 Monoclonal Antibody |
| Product Code: | CAB22329 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC51158 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:10000-1:20000, FC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | THP-1, U-937, Mouse spleen, Rat lung |
| Cellular Location: | Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein, Single-pass type I membrane protein |
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CD68 (NP_001242.2). |
| Sequence: | TSQGP STATH SPATT SHGNA TVHPT SNSTA TSPGF TSSAH PEPPP PSPSP SPTSK ETIGD YTWTN GSQPC VHLQA QIQIR VMYTT QGGGE AWGIS VLNPN K |
| Synonyms: | GP110, LAMP4, SCARD1 |
| Calculated MW: | 37kDa |
| Observed MW: | 70-80kDa, 130-140kDa |
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