CD62L monoclonal antibody (APC ) (AGIM0481)

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SKU:
AGIM0481
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
HI62L
Conjugation:
APC
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD62L monoclonal antibody (APC )
Product Code:AGIM0481
Size:100 µL
Reactivity:Human
Clone:HI62L
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P14151
Background:CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activationdependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (Pselectin glycoprotein ligand-1).
UniProt Protein Function:SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23-q25

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:heparin binding; protein binding; protease binding; cell adhesion molecule binding; glycosphingolipid binding; carbohydrate binding

Biological Process: regulation of immune response; blood coagulation; cell adhesion; leukocyte migration; response to ATP

Disease: Iga Nephropathy, Susceptibility To, 1

NCBI Summary:This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Code:P14151
NCBI GenInfo Identifier:126178
NCBI Gene ID:6402
NCBI Accession:P14151.2
UniProt Secondary Accession:P14151,P15023, Q9UJ43, B2R6Q8,
UniProt Related Accession:P14151
Molecular Weight:43,618 Da
NCBI Full Name:L-selectin
NCBI Synonym Full Names:selectin L
NCBI Official Symbol:SELL  
NCBI Official Synonym Symbols:TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1  
NCBI Protein Information:L-selectin; gp90-MEL; pln homing receptor; lymph node homing receptor; lymphocyte adhesion molecule 1; leukocyte surface antigen Leu-8; CD62 antigen-like family member L; leukocyte-endothelial cell adhesion molecule 1
UniProt Protein Name:L-selectin
UniProt Synonym Protein Names:CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L
Protein Family:L-selectin
UniProt Gene Name:SELL  
UniProt Entry Name:LYAM1_HUMAN
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