CD59 (no azide) monoclonal antibody (AGIM0054)
- SKU:
- AGIM0054
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- MEM-43
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD59 (no azide) monoclonal antibody |
| Product Code: | AGIM0054 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | MEM-43 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG2a |
| Host Species: | Mouse |
| Storage: | Aliquot and store at -20°C. Avoid freeze/thaw cycles. Should be handled underaseptic conditions. |
| Uniprot: | P13987 |
| Background: | CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation. This material is offered for research only. Not for use in human. For in vitro use only. ImmunoTools will not be held responsible for patent infringement or other violations that may occur with the use of our products. |
| UniProt Protein Function: | CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D). |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 11p13 Cellular Component: anchored to external side of plasma membrane; cell surface; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; extracellular space; focal adhesion; Golgi membrane; membrane; plasma membrane; vesicle Molecular Function:complement binding; protein binding Biological Process: blood coagulation; cell activation; cell surface receptor linked signal transduction; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; neutrophil degranulation; regulation of complement activation Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy |
| NCBI Summary: | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13987 |
| NCBI GenInfo Identifier: | 116021 |
| NCBI Gene ID: | 966 |
| NCBI Accession: | P13987.1 |
| UniProt Related Accession: | P13987 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | CD59 glycoprotein |
| NCBI Synonym Full Names: | CD59 molecule (CD59 blood group) |
| NCBI Official Symbol: | CD59 |
| NCBI Official Synonym Symbols: | 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20 |
| NCBI Protein Information: | CD59 glycoprotein |
| UniProt Protein Name: | CD59 glycoprotein |
| UniProt Synonym Protein Names: | 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD_antigen: CD59 |
| Protein Family: | CD59 glycoprotein |
| UniProt Gene Name: | CD59 |
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