Cd46 Antibody (PACO25600)
- SKU:
- PACO25600
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Cd46 Antibody (PACO25600) |
| Antibody SKU: | PACO25600 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Membrane cofactor protein (45-329AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Mouse skeletal muscle tissue All lanes: Cd46 antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 41, 34 kDa Observed band size: 41 kDa . |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO25600 at dilution of 1:100. |
| Synonyms: | Membrane cofactor protein (CD antigen CD46), Cd46, Mcp |
| UniProt Protein Function: | CD46: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations. 16 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.; Membrane protein, integral; Cell surfaceCellular Component: Golgi apparatus; inner acrosomal membrane; focal adhesion; cell surface; membrane; basolateral plasma membrane; cytoplasm; integral to membrane; acrosome; extracellular region; cytoplasmic vesicleMolecular Function: enzyme inhibitor activity; complement binding; cadherin binding; endopeptidase activityBiological Process: positive regulation of memory T cell differentiation; positive regulation of regulatory T cell differentiation; regulation of Notch signaling pathway; negative regulation of complement activation; single fertilization; T cell mediated immunity; negative regulation of catalytic activity; interleukin-10 production; positive regulation of T cell proliferation; proteolysis; positive regulation of interleukin-10 production |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O88174 |
| NCBI GenInfo Identifier: | 6754660 |
| NCBI Gene ID: | 17221 |
| NCBI Accession: | NP_034908.1 |
| UniProt Secondary Accession: | O88174,Q9R0R9 |
| UniProt Related Accession: | O88174 |
| Molecular Weight: | 55.2kDa |
| NCBI Full Name: | membrane cofactor protein |
| NCBI Synonym Full Names: | CD46 antigen, complement regulatory protein |
| NCBI Official Symbol: | Cd46 |
| NCBI Official Synonym Symbols: | Mcp |
| NCBI Protein Information: | membrane cofactor protein |
| UniProt Protein Name: | Membrane cofactor protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | Cd46 |
| UniProt Entry Name: | MCP_MOUSE |
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