CD45RB Polyclonal Antibody
- SKU:
- CAB23258
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | CD45RB Polyclonal Antibody |
| Product Code: | CAB23258 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat |
| Cellular Location: | Membrane, Membrane raft, Single-pass type I membrane protein |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-463 of human CD45RB. (XP_006711537.1). |
| Sequence: | QSPTP SPTGV SSVQT PHLPT HADSQ TPSAG TDTQT FSGSA ANAKL NPTPG SNAIS DAYLN ASETT TLSPS GSAVI STTTI ATTPS KPTCD EKYAN ITVDY LYNKE TKLFT AKLNV NENVE CGNNT CTNNE VHNLT ECKNA SVSIS HNSCT APDKT LILDV PPGVE KFQLH DCTQV EKADT TICLK WKNIE TFTCD TQNIT YRFQC GNMIF DNKEI KLENL EPEHE YKCDS EILYN NHKFT NASKI IKTDF GSPGE PQIIF CRSEA AHQGV ITWNP PQRSF HNFTL CYIKE TEKDC LNLDK NLIKY DLQNL KPYTK YVLSL HAYII AKVQR NGSAA MCHFT TKSAP PSQVW NMTVS MTSDN SMHVK CRPPR DRNGP HERYH LEVEA GNTLV RNESH KNCDF RVKDL QYSTD YTFKA YFHNG DYPGE PFILH HSTSY NSK |
| Synonyms: | LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180, IMD105 |
| Calculated MW: | 135kDa |
| Observed MW: | 200-250kDa |
Related Products
GATA3 Polyclonal Antibody
AMPKγ1 Polyclonal Antibody
NXPH1 Polyclonal Antibody
Rv0222 Polyclonal Antibody
