CD45 Monoclonal Antibody (CAB23503)
- SKU:
- CAB23503
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | CD45 Monoclonal Antibody |
| Product Code: | CAB23503 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52280 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500, -1:1000, IHC-P 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat |
| Cellular Location: | Membrane, Membrane raft, Single-pass type I membrane protein |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
| Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 194-390 of human CD45 (NP_002829.3). |
| Sequence: | SDAYL NASET TTLSP SGSAV ISTTT IATTP SKPTC DEKYA NITVD YLYNK ETKLF TAKLN VNENV ECGNN TCTNN EVHNL TECKN ASVSI SHNSC TAPDK TLILD VPPGV EKFQL HDCTQ VEKAD TTICL KWKNI ETFTC DTQNI TYRFQ CGNMI FDNKE IKLEN LEPEH EYKCD SEILY NNHKF TNASK IIKTD FG |
| Synonyms: | LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180, IMD105 |
| Calculated MW: | 147kDa |
| Observed MW: | Refer to figures |
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