CD45/Dy647 monoclonal antibody (PE/Dy647 ) (AGIM0398)

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SKU:
AGIM0398
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-28 (mouse)
Conjugation:
PE/Dy647
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD45/Dy647 monoclonal antibody (PE/Dy647 )
Product Code:AGIM0398
Size:100 µL
Reactivity:Human
Clone:MEM-28 (mouse)
Applications:Flow Cytometry
Conjugate:PE/Dy647
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:P08575
Background:CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
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