CD42b monoclonal antibody (PE) (AGIM0360)
- SKU:
- AGIM0360
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- HIP1
- Conjugation:
- PE
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD42b monoclonal antibody (PE) |
| Product Code: | AGIM0360 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | HIP1 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | O00291 |
| Background: | CD42b (GPIb?±) composes together with GPIb??, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. |
| UniProt Protein Function: | HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Apoptosis Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: Golgi apparatus; cytoskeleton; intracellular membrane-bound organelle; clathrin-coated vesicle; membrane; cytoplasm; clathrin coated vesicle membrane; nucleus Molecular Function:protein binding, bridging; clathrin binding; protein binding; structural constituent of cytoskeleton; actin binding; phosphoinositide binding Biological Process: regulation of apoptosis; caspase activation; clathrin cage assembly; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; endocytosis; cell differentiation; actin cytoskeleton organization and biogenesis; positive regulation of receptor-mediated endocytosis Disease: Prostate Cancer |
| NCBI Summary: | The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O00291 |
| NCBI GenInfo Identifier: | 206729937 |
| NCBI Gene ID: | 3092 |
| NCBI Accession: | O00291.5 |
| UniProt Related Accession: | O00291 |
| Molecular Weight: | ~ 116kDa |
| NCBI Full Name: | Huntingtin-interacting protein 1 |
| NCBI Synonym Full Names: | huntingtin interacting protein 1 |
| NCBI Official Symbol: | HIP1 |
| NCBI Official Synonym Symbols: | SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma |
| NCBI Protein Information: | huntingtin-interacting protein 1 |
| UniProt Protein Name: | Huntingtin-interacting protein 1 |
| UniProt Synonym Protein Names: | Huntingtin-interacting protein I; HIP-I |
| Protein Family: | Histidine permease |
| UniProt Gene Name: | HIP1 |
| UniProt Entry Name: | HIP1_HUMAN |
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