CD42b Monoclonal Antibody
- SKU:
- CAB22277
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | CD42b Monoclonal Antibody |
| Product Code: | CAB22277 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC56624 |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HEL |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-531 of human CD42b (NP_000164.5). |
| Sequence: | HPHPI CEVSK VASHL EVNCD KRNLT ALPPD LPKDT TILHL SENLL YTFSL ATLMP YTRLT QLNLD RCELT KLQVD GTLPV LGTLD LSHNQ LQSLP LLGQT LPALT VLDVS FNRLT SLPLG ALRGL GELQE LYLKG NELKT LPPGL LTPTP KLEKL SLANN NLTEL PAGLL NGLEN LDTLL LQENS LYTIP KGFFG SHLLP FAFLH GNPWL CNCEI LYFRR WLQDN AENVY VWKQG VDVKA MTSNV ASVQC DNSDK FPVYK YPGKG CPTLG DEGDT DLYDY YPEED TEGDK VRATR TVVKF PTKAH TTPWG LFYSW STASL DSQMP SSLHP TQEST KEQTT FPPRW TPNFT LHMES ITFSK TPKST TEPTP SPTTS EPVPE PAPNM TTLEP TPSPT TPEPT SEPAP SPTTP EPTSE PAPSP TTPEP TSEPA PSPTT PEPTP IPTIA TSPTI LVSAT SLITP KSTFL TTTKP VSLLE STKKT IPELD QPPKL RGVLQ GHLES SRNDP FLHPD FCCLL PL |
| Synonyms: | BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3, GPIbalpha, CD42b-alpha |
| Calculated MW: | 72kDa |
| Observed MW: | 140kDa |
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