CD4 monoclonal antibody (AGIM0149)
- SKU:
- AGIM0149
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1k
- Clone:
- IT4
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD4 monoclonal antibody |
| Product Code: | AGIM0149 |
| Size: | 100 µg in100 µL |
| Reactivity: | Human |
| Clone: | IT4 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1k |
| Host Species: | Mouse |
| Storage: | Aliquot and store at -20°C. Avoid freeze/thaw cycles. Should be handled under asepticconditions. |
| Background: | CD4 is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1); IL-16 (binds to CD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin - Intracellular ligands: p56Lck CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus; CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency). |
Related Products
CD4 Monoclonal Antibody
OverviewProduct Name:CD4 Monoclonal AntibodyProduct Code:CAB24719Reactivity:MouseApplications:Western blotting, Immunoprecipitati
![CD4 Monoclonal Monoclonal Antibody, Biotin [mCD4] (CPAB0370)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58592/63774/cd4-monoclonal-monoclonal-antibody-biotin-mcd4-cpab0370__87976__53459.1706535152.jpg?c=1 "CD4 Monoclonal Monoclonal Antibody, Biotin [mCD4] (CPAB0370)")
