CD4 monoclonal antibody (AGIM0149)

Name: CD4 monoclonal antibody (AGIM0149)
SKU: AGIM0149
Availability: OutOfStock

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OverviewProduct Name:CD4 Monoclonal AntibodyProduct Code:CAB24719Reactivity:MouseApplications:Western blotting, Immunoprecipitati

system_update_altDatasheetOverview

system_update_altDatasheetOverview

system_update_alt Datasheet Overview

system_update_altDatasheetOverview

Isotype:	IgG1k
Host Species:	Mouse
Storage:	Aliquot and store at -20°C. Avoid freeze/thaw cycles. Should be handled under asepticconditions.
Background:	CD4 is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1); IL-16 (binds to CD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin - Intracellular ligands: p56Lck CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus; CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).