CD3G Protein Recombinant Protein (RPPB3062)

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SKU:
RPPB3062
Product Type:
Recombinant Protein
Uniprot:
P09693

Description

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Product Name:CD3G Protein Recombinant Protein
Product Code:RPPB3062
Size:20µg
Target:CD3G Protein
Synonyms:T-cell surface glycoprotein CD3 gamma chain, CD3-GAMMA, T3G, CD3G.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CD3G protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATIS

CD3-gamma polypeptide is encoded by CD3 Gamma (CD3G) which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, configures the T-cell receptor-CD3 complex. The T-cell receptor-CD3 complex takes part in coupling antigen recognition to numerous intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Deficiencies in this gene are associated with T cell immunodeficiency.

CD3G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids (23-116a.a.) and having a molecular mass of 13.1kDa. CD3G is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
NCBI Summary:The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
UniProt Code:P09693
NCBI GenInfo Identifier:115993
NCBI Gene ID:917
NCBI Accession:P09693.1
UniProt Secondary Accession:P09693,Q2HIZ6,
UniProt Related Accession:P09693
Molecular Weight:20,469 Da
NCBI Full Name:T-cell surface glycoprotein CD3 gamma chain
NCBI Synonym Full Names:CD3g molecule
NCBI Official Symbol:CD3G��
NCBI Official Synonym Symbols:T3G; IMD17; CD3-GAMMA��
NCBI Protein Information:T-cell surface glycoprotein CD3 gamma chain
UniProt Protein Name:T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names:T-cell receptor T3 gamma chain; CD_antigen: CD3g
Protein Family:T-cell surface glycoprotein
UniProt Gene Name:CD3G��
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