CD38 monoclonal antibody (PE) (AGIM0357)

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SKU:
AGIM0357
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HIT2
Conjugation:
PE
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD38 monoclonal antibody (PE)
Product Code:AGIM0357
Size:100 µL
Reactivity:Human
Clone:HIT2
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light. The reagent is stable until the expirydate stated on the vial label.
Uniprot:P28907
Background:CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
UniProt Protein Function:CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.2.2.6; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Hydrolase; Cell surface; Apoptosis; Lyase; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function:transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis

NCBI Summary:CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]
UniProt Code:P28907
NCBI GenInfo Identifier:55977782
NCBI Gene ID:952
NCBI Accession:P28907.2
UniProt Secondary Accession:P28907,O00121, O00122, Q96HY4,
UniProt Related Accession:P28907
Molecular Weight:300
NCBI Full Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
NCBI Synonym Full Names:CD38 molecule
NCBI Official Symbol:CD38  
NCBI Official Synonym Symbols:T10; ADPRC 1  
NCBI Protein Information:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
UniProt Protein Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Synonym Protein Names:2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
Protein Family:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name:CD38  
UniProt Entry Name:CD38_HUMAN
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