CD33 monoclonal antibody (PE) (AGIM0355)

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SKU:
AGIM0355
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HIM3-4
Conjugation:
PE
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD33 monoclonal antibody (PE)
Product Code:AGIM0355
Size:100 µL
Reactivity:Human
Clone:HIM3-4
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P20138
Background:CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.
UniProt Protein Function:CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:protein binding; receptor activity; carbohydrate binding

Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion

UniProt Code:P20138
NCBI GenInfo Identifier:116241290
NCBI Gene ID:945
NCBI Accession:P20138.2
UniProt Secondary Accession:P20138,Q8TD24, B4E3P8, C9JEN7, F8WAL2,
UniProt Related Accession:P20138
Molecular Weight:Calculated MW: 25kDa/33kDa/39kDaObserved MW: 77kDa
NCBI Full Name:Myeloid cell surface antigen CD33
NCBI Synonym Full Names:CD33 molecule
NCBI Official Symbol:CD33  
NCBI Official Synonym Symbols:p67; SIGLEC3; SIGLEC-3  
NCBI Protein Information:myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3
UniProt Protein Name:Myeloid cell surface antigen CD33
UniProt Synonym Protein Names:Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33
Protein Family:Myeloid cell surface antigen
UniProt Gene Name:CD33  
UniProt Entry Name:CD33_HUMAN
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