CD305/LAIR1 Monoclonal Antibody
- SKU:
- CAB23775
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- FC
Description
| Product Name: | CD305/LAIR1 Monoclonal Antibody |
| Product Code: | CAB23775 |
| Reactivity: | Human |
| Applications: | Western blotting, Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC61434 |
| Reactivity: | Human |
| Tested Applications: | WB, FC, ELISA |
| Key Applications: | Western blotting, Flow Cytometry |
| Recommended Dilution: | WB 1:1000-1:5000, FC 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | THP-1 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-163 of human CD305/LAIR1(NP_002278.2). |
| Sequence: | EDLPR PSISA EPGTV IPLGS HVTFV CRGPV GVQTF RLERD SRSTY NDTED VSQAS PSESE ARFRI DSVRE GNAGL YRCIY YKPPK WSEQS DYLEL LVKES SGGPD SPDTE PGSSA GPTQR PSDNS HNEHA PASQG LKAEH |
| Synonyms: | LAIR1, CD305, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1 |
| Calculated MW: | 23kDa/29kDa/31kDa |
| Observed MW: | 40-50kDa |
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