CD3 monoclonal antibody (PE) (AGIM0030)

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SKU:
AGIM0030
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
MEM-57 (mouse)
Conjugation:
PE
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD3 monoclonal antibody (PE)
Product Code:AGIM0030
Size:500 µL
Reactivity:Human
Clone:MEM-57 (mouse)
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:P04234
Background:CD3 complex is crucial in transducing antigen-recognition signals into the cytopasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosinebased motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation . The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
UniProt Protein Function:CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex

Molecular Function:transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection

Disease: Immunodeficiency 19

NCBI Summary:The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
UniProt Code:P04234
NCBI GenInfo Identifier:115985
NCBI Gene ID:915
NCBI Accession:P04234.1
UniProt Secondary Accession:P04234,A8MVP6,
UniProt Related Accession:P04234
Molecular Weight:171
NCBI Full Name:T-cell surface glycoprotein CD3 delta chain
NCBI Synonym Full Names:CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol:CD3D  
NCBI Official Synonym Symbols:T3D; IMD19; CD3-DELTA  
NCBI Protein Information:T-cell surface glycoprotein CD3 delta chain; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex)
UniProt Protein Name:T-cell surface glycoprotein CD3 delta chain
UniProt Synonym Protein Names:T-cell receptor T3 delta chain; CD_antigen: CD3d
Protein Family:CD302 antigen
UniProt Gene Name:CD3D  
UniProt Entry Name:CD3D_HUMAN
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