CD29 monoclonal antibody (AGIM0040)

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SKU:
AGIM0040
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-101A
Conjugation:
Unconjugated
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD29 monoclonal antibody
Product Code:AGIM0040
Size:100 µg in 100 µL
Reactivity:Human, Porcine, Canine
Clone:MEM-101A
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at 20°C. Avoid freeze/thaw cycles.
Uniprot:P05556
Background:CD29 (??1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 dibberent ?± chains (?±1-?±6, CD49a-f) determining the binding properties of ??1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most ??1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of ??1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a ??1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1??.
UniProt Protein Function:ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin.. Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).
UniProt Protein Details:

Protein type:Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 10p11.22

Cellular Component: cell surface; cell-cell adherens junction; cytoplasm; filopodium; focal adhesion; lipid raft; membrane; neuromuscular junction; plasma membrane; receptor complex; ruffle; sarcolemma

Molecular Function:actin binding; C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; fibronectin binding; protease binding; protein binding; protein complex binding; protein heterodimerization activity

Biological Process: B cell differentiation; calcium-independent cell-matrix adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular defense response; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; homophilic cell adhesion; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; leukocyte tethering or rolling; mesodermal cell differentiation; positive regulation of apoptosis; positive regulation of GTPase activity; receptor internalization; regulation of immune response; stress fiber formation; transforming growth factor beta receptor signaling pathway

NCBI Summary:Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P05556
NCBI GenInfo Identifier:218563324
NCBI Gene ID:3688
NCBI Accession:P05556.2
UniProt Secondary Accession:P05556,P78466, P78467, Q13089, Q13090, Q13091, Q13212 A8K6N2, D3DRX9, D3DRY3, D3DRY4, D3DRY5,
UniProt Related Accession:P05556
Molecular Weight:88,884 Da
NCBI Full Name:Integrin beta-1
NCBI Synonym Full Names:integrin subunit beta 1
NCBI Official Symbol:ITGB1  
NCBI Official Synonym Symbols:CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA  
NCBI Protein Information:integrin beta-1
UniProt Protein Name:Integrin beta-1
UniProt Synonym Protein Names:Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD_antigen: CD29
UniProt Gene Name:ITGB1  
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