CD28 (no azide) monoclonal antibody (AGIM0039)
- SKU:
- AGIM0039
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- CD28.2
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD28 (no azide) monoclonal antibody |
| Product Code: | AGIM0039 |
| Size: | 100 µg |
| Reactivity: | Human |
| Clone: | CD28.2 |
| Applications: | Flow Cytometry, Western Blot, Immunohistochemistry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Storage conditions:Aliquot and store at -20°C. Avoid freeze/thaw cycles. Should be handled under aseptic conditions. |
| Uniprot: | P10747 |
| Background: | CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader. This material is offered for research only. Not for use in human. For in vitro use only. ImmunoTools will not be held responsible for patent infringement or other violations that may occur with the use of our products. . |
| UniProt Protein Function: | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). |
| NCBI Summary: | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P10747 |
| NCBI GenInfo Identifier: | 115973 |
| NCBI Gene ID: | 940 |
| NCBI Accession: | P10747.1 |
| UniProt Secondary Accession: | P10747,Q13964, Q52M23, Q70WG0, Q8NI54, Q8NI55, Q8NI56 Q8WXJ2, Q9BYV0, A8KAC1, |
| UniProt Related Accession: | P10747 |
| Molecular Weight: | 26,186 Da |
| NCBI Full Name: | T-cell-specific surface glycoprotein CD28 |
| NCBI Synonym Full Names: | CD28 molecule |
| NCBI Official Symbol: | CD28 |
| NCBI Official Synonym Symbols: | Tp44 |
| NCBI Protein Information: | T-cell-specific surface glycoprotein CD28 |
| UniProt Protein Name: | T-cell-specific surface glycoprotein CD28 |
| UniProt Synonym Protein Names: | TP44; CD_antigen: CD28 |
| Protein Family: | T-cell-specific surface glycoprotein |
| UniProt Gene Name: | CD28 |
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