CD276 Polyclonal Antibody
- SKU:
- CAB24668
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | CD276 Polyclonal Antibody |
| Product Code: | CAB24668 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | U-2 OS, LNCaP |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 29-245 of human CD276(NP_079516.1). |
| Sequence: | LEVQV PEDPV VALVG TDATL CCSFS PEPGF SLAQL NLIWQ LTDTK QLVHS FAEGQ DQGSA YANRT ALFPD LLAQG NASLR LQRVR VADEG SFTCF VSIRD FGSAA VSLQV AAPYS KPSMT LEPNK DLRPG DTVTI TCSSY RGYPE AEVFW QDGQG VPLTG NVTTS QMANE QGLFD VHSVL RVVLG ANGTY SCLVR NPVLQ QDAHG SVTIT GQPMT FP |
| Synonyms: | B7H3, B7-H3, B7RP-2, 4Ig-B7-H3 |
| Calculated MW: | 33kDa |
| Observed MW: | 100kDa |
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