CD276/B7-H3 Polyclonal Antibody (CAB21663)
- SKU:
- CAB21663
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | CD276/B7-H3 Polyclonal Antibody |
| Product Code: | CAB21663 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 60-159 of human CD276/B7-H3 (NP_001019907.1). |
| Sequence: | LAQLN LIWQL TDTKQ LVHSF AEGQD QGSAY ANRTA LFPDL LAQGN ASLRL QRVRV ADEGS FTCFV SIRDF GSAAV SLQVA APYSK PSMTL EPNKD LRPGD |
| Synonyms: | B7H3, B7-H3, B7RP-2, 4Ig-B7-H3 |
| Calculated MW: | 57kDa |
| Observed MW: | Refer to figures |
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