CD25 Monoclonal Antibody (CAB23153)
- SKU:
- CAB23153
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | CD25 Monoclonal Antibody |
| Product Code: | CAB23153 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC58173 |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:20000, IF/ICC 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T-CD25 |
| Cellular Location: | cell surface, external side of plasma membrane |
| Customer Validation: | IHC(Homo sapiens ) |
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-213 of human CD25 (NP_000408.1). |
| Sequence: | ELCDD DPPEI PHATF KAMAY KEGTM LNCEC KRGFR RIKSG SLYML CTGNS SHSSW DNQCQ CTSSA TRNTT KQVTP QPEEQ KERKT TEMQS PMQPV DQASL PGHCR EPPPW ENEAT ERIYH FVVGQ MVYYQ CVQGY RALHR GPAES VCKMT HGKTR WTQPQ LICTG EMETS QFPGE EKPQA SPEGR PESET SC |
| Synonyms: | p55, CD25, IL2R, IMD41, TCGFR, IDDM10 |
| Calculated MW: | 31kDa |
| Observed MW: | 45-75kDa |
Related Products
CD25 Monoclonal Antibody (CAB22479)
CD25 Monoclonal Antibody (CAB242128)
