CD25 monoclonal antibody (APC) (AGIM0467)
- SKU:
- AGIM0467
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- MEM-181
- Conjugation:
- APC
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD25 monoclonal antibody (APC) |
| Product Code: | AGIM0467 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | MEM-181 |
| Applications: | Flow Cytometry |
| Conjugate: | APC |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P01589 |
| Background: | CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas. |
| UniProt Protein Function: | IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: plasma membrane Molecular Function:interleukin-2 binding; Ras guanyl-nucleotide exchange factor activity Biological Process: apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; MAPKKK cascade; regulation of T cell tolerance induction Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of |
| NCBI Summary: | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] |
| UniProt Code: | P01589 |
| NCBI GenInfo Identifier: | 124317 |
| NCBI Gene ID: | 3559 |
| NCBI Accession: | P01589.1 |
| UniProt Secondary Accession: | P01589,Q5W007, |
| UniProt Related Accession: | P01589 |
| Molecular Weight: | 30,819 Da |
| NCBI Full Name: | Interleukin-2 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 2 receptor subunit alpha |
| NCBI Official Symbol: | IL2RA |
| NCBI Official Synonym Symbols: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| NCBI Protein Information: | interleukin-2 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-2 receptor subunit alpha |
| UniProt Synonym Protein Names: | TAC antigen; p55; CD_antigen: CD25 |
| UniProt Gene Name: | IL2RA |
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