CD21 monoclonal antibody (PE) (AGIM0351)

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SKU:
AGIM0351
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
LT21
Conjugation:
PE
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD21 monoclonal antibody (PE)
Product Code:AGIM0351
Size:100 µL
Reactivity:Human
Clone:LT21
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light
Uniprot:P20023
Background:CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
UniProt Protein Function:CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: receptor complex

Molecular Function:complement binding; DNA binding; protein homodimerization activity

Biological Process: B cell differentiation; B cell proliferation

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 7; Systemic Lupus Erythematosus, Susceptibility To, 9

NCBI Summary:This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:P20023
NCBI GenInfo Identifier:215273962
NCBI Gene ID:1380
NCBI Accession:P20023.2
UniProt Secondary Accession:P20023,Q13866, Q14212, Q53EL2, Q5BKT9, Q5SR46, Q5SR48 C9JHD2,
UniProt Related Accession:P20023
Molecular Weight:
NCBI Full Name:Complement receptor type 2
NCBI Synonym Full Names:complement component 3d receptor 2
NCBI Official Symbol:CR2  
NCBI Official Synonym Symbols:CR; C3DR; CD21; CVID7; SLEB9  
NCBI Protein Information:complement receptor type 2
UniProt Protein Name:Complement receptor type 2
UniProt Synonym Protein Names:Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21
Protein Family:Complement receptor
UniProt Gene Name:CR2  
UniProt Entry Name:CR2_HUMAN
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