CD1a monoclonal antibody (PE) (AGIM0021)

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SKU:
AGIM0021
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HI149
Conjugation:
PE
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD1a monoclonal antibody (PE)
Product Code:AGIM0021
Size:500 µL
Reactivity:Human
Clone:HI149
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P06126
Background:CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
UniProt Protein Function:Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
NCBI Summary:This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:P06126
NCBI GenInfo Identifier:288558852
NCBI Gene ID:909
NCBI Accession:P06126.4
UniProt Related Accession:P06126
Molecular Weight:
NCBI Full Name:T-cell surface glycoprotein CD1a
NCBI Synonym Full Names:CD1a molecule
NCBI Official Symbol:CD1A  
NCBI Official Synonym Symbols:R4; T6; CD1; FCB6; HTA1  
NCBI Protein Information:T-cell surface glycoprotein CD1a
UniProt Protein Name:T-cell surface glycoprotein CD1a
UniProt Synonym Protein Names:T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a
Protein Family:CD109 antigen
UniProt Gene Name:CD1A  
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