Description
system_update_altDatasheet
Product Name: | CD177 monoclonal antibody |
Product Code: | AGIM0093 |
Size: | 100 µg in 100 µL |
Reactivity: | Human |
Clone: | MEM-166 |
Applications: | Flow Cytometry |
Conjugate: | Unconjugated |
Isotype: | IgG1 |
Host Species: | Mouse |
Storage: | Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
Uniprot: | Q8N6Q3 |
Background: | The purified antibody is conjugated with R-Phycoerythrin (R-PE) under optimum conditions. The conjuate is purified by size-exclusion chromotography and adjusted for direct use. No reconstitution is necessary. |
UniProt Protein Function: | CD177: Induced by CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET). 3 isoforms of the human protein are produced by alternative splicing |
UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: plasma membrane Biological Process: blood coagulation; leukocyte migration |
NCBI Summary: | This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014] |
UniProt Code: | Q8N6Q3 |
NCBI GenInfo Identifier: | 91208246 |
NCBI Gene ID: | 57126 |
NCBI Accession: | Q8N6Q3.2 |
UniProt Secondary Accession: | Q8N6Q3,Q711Q2, Q8NCV9, Q96QH1, Q9HDA5, |
UniProt Related Accession: | Q8N6Q3 |
Molecular Weight: | 437 |
NCBI Full Name: | CD177 antigen |
NCBI Synonym Full Names: | CD177 molecule |
NCBI Official Symbol: | CD177 |
NCBI Official Synonym Symbols: | NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP |
NCBI Protein Information: | CD177 antigen; NB1 glycoprotein; cell surface receptor; human neutrophil alloantigen 2a; polycythemia rubra vera protein 1 |
UniProt Protein Name: | CD177 antigen |
UniProt Synonym Protein Names: | Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD_antigen: CD177 |
Protein Family: | CD177 antigen |
UniProt Gene Name: | CD177 |
UniProt Entry Name: | CD177_HUMAN |