CD177 Monoclonal Antibody
- SKU:
- CAB24263
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | CD177 Monoclonal Antibody |
| Product Code: | CAB24263 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC62893 |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | RPMI 8226 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to aminoacids 22-407 of human CD177(NP_065139.2). |
| Sequence: | LLCQF GTVQH VWKVS DLPRQ WTPKN TSCDS GLGCQ DTLML IESGP QVSLV LSKGC TEAKD QEPRV TEHRM GPGLS LISYT FVCRQ EDFCN NLVNS LPLWA PQPPA DPGSL RCPVC LSMEG CLEGT TEEIC PKGTT HCYDG LLRLR GGGIF SNLRV QGCMP QPGCN LLNGT QEIGP VGMTE NCNRK DFLTC HRGTT IMTHG NLAQE PTDWT TSNTE MCEVG QVCQE TLLLL DVGLT STLVG TKGCS TVGAQ NSQKT TIHSA PPGVL VASYT HFCSS DLCNS ASSSS VLLNS LPPQA APVPG DRQCP TCVQP LGTCS SGSPR MTCPR GATHC YDGYI HLSGG GLSTK MSIQG CVAQP SSFLL NHTRQ IGIFS AREKR DVQPP ASQHE G |
| Synonyms: | NB1, PRV1, HNA2A, PRV-1, HNA-2a, NB1 GP |
| Calculated MW: | 51kDa |
| Observed MW: | 40-65kDa |
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