CD16 monoclonal antibody (APC) (AGIM0463)

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SKU:
AGIM0463
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
LNK16
Conjugation:
APC
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD16 monoclonal antibody (APC)
Product Code:AGIM0463
Size:100 µL
Reactivity:Human
Clone:LNK16
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P08637
Background:CD16 (Fc??RIII) is a 50-80 kDa glycoprotein serving as a low affinity IgG receptor. Human Fc??RIII is expressed in two forms Fc??RIII-A and ??“B. Fc??RIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with Fc?µRI-?? subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell Fc??RIII-A is associated, moreover, with Fc?µRI-?? subunit. Besides IgG, Fc?µRI-A can be triggered also by oligomeric IgE. Fc??RIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
UniProt Protein Function:FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function:IgG binding

Biological Process: regulation of immune response; innate immune response; immune response

Disease: Immunodeficiency 20

NCBI Summary:This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P08637
NCBI GenInfo Identifier:119876
NCBI Gene ID:2214
NCBI Accession:P08637.2
UniProt Secondary Accession:P08637,Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0, A2N6W9
UniProt Related Accession:P08637
Molecular Weight:254
NCBI Full Name:Low affinity immunoglobulin gamma Fc region receptor III-A
NCBI Synonym Full Names:Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Official Symbol:FCGR3A  
NCBI Official Synonym Symbols:CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA  
NCBI Protein Information:low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-
UniProt Protein Name:Low affinity immunoglobulin gamma Fc region receptor III-A
UniProt Synonym Protein Names:CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a
Protein Family:CD160 antigen
UniProt Gene Name:FCGR3A  
UniProt Entry Name:FCG3A_HUMAN
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