CD152/CTLA-4 Monoclonal Antibody

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SKU:
CAB22865
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:CD152/CTLA-4 Monoclonal Antibody
Product Code:CAB22865
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC57390
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:2000-1:10000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:293F
Cellular Location:Cell membrane

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 37-162 of human CD152/CTLA-4 (NP_005205.2).
Sequence:AMHVA QPAVV LASSR GIASF VCEYA SPGKA TEVRV TVLRQ ADSQV TEVCA ATYMM GNELT FLDDS ICTGT SSGNQ VNLTI QGLRA MDTGL YICKV ELMYP PPYYL GIGNG TQIYV IDPEP CPDSD F
Synonyms:CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3
Calculated MW:25kDa
Observed MW:25kDa
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