CD152/CTLA-4 Monoclonal Antibody
- SKU:
- CAB22865
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | CD152/CTLA-4 Monoclonal Antibody |
| Product Code: | CAB22865 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57390 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:10000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293F |
| Cellular Location: | Cell membrane |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-162 of human CD152/CTLA-4 (NP_005205.2). |
| Sequence: | AMHVA QPAVV LASSR GIASF VCEYA SPGKA TEVRV TVLRQ ADSQV TEVCA ATYMM GNELT FLDDS ICTGT SSGNQ VNLTI QGLRA MDTGL YICKV ELMYP PPYYL GIGNG TQIYV IDPEP CPDSD F |
| Synonyms: | CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3 |
| Calculated MW: | 25kDa |
| Observed MW: | 25kDa |
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