CD141/Thrombomodulin Monoclonal Antibody (CAB21238)
- SKU:
- CAB21238
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
- Applications:
- IF
- Applications:
- FC
Description
| Product Name: | CD141/Thrombomodulin Monoclonal Antibody |
| Product Code: | CAB21238 |
| Reactivity: | Human |
| Applications: | Immunohistochemistry, Immunofluorescence, Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52600 |
| Reactivity: | Human |
| Tested Applications: | IHC-P, IF/ICC, FC, ELISA |
| Key Applications: | Immunohistochemistry, Immunofluorescence, Flow Cytometry |
| Recommended Dilution: | IHC-P 1:500-1:1000, IF/ICC 1:50-1:200, FC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Membrane |
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-515 of human CD141/Thrombomodulin (NP_000352.1). |
| Sequence: | APAEP QPGGS QCVEH DCFAL YPGPA TFLNA SQICD GLRGH LMTVR SSVAA DVISL LLNGD GGVGR RRLWI GLQLP PGCGD PKRLG PLRGF QWVTG DNNTS YSRWA RLDLN GAPLC GPLCV AVSAA EATVP SEPIW EEQQC EVKAD GFLCE FHFPA TCRPL AVEPG AAAAA VSITY GTPFA ARGAD FQALP VGSSA AVAPL GLQLM CTAPP GAVQG HWARE APGAW DCSVE NGGCE HACNA IPGAP RCQCP AGAAL QADGR SCTAS ATQSC NDLCE HFCVP NPDQP GSYSC MCETG YRLAA DQHRC EDVDD CILEP SPCPQ RCVNT QGGFE CHCYP NYDLV DGECV EPVDP CFRAN CEYQC QPLNQ TSYLC VCAEG FAPIP HEPHR CQMFC NQTAC PADCD PNTQA SCECP EGYIL DDGFI CTDID ECENG GFCSG VCHNL PGTFE CICGP DSALA RHIGT DCDSG KVDGG DSGSG EPPPS PTPGS TLTPP AVGLV HS |
| Synonyms: | TM, THRM, AHUS6, BDCA3, CD141, BDCA-3, THPH12 |
| Calculated MW: | 60kDa |
| Observed MW: | Refer to figures |
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