CD140b/PDGFRB Monoclonal Antibody
- SKU:
- CAB23952
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- FC
Description
| Product Name: | CD140b/PDGFRB Monoclonal Antibody |
| Product Code: | CAB23952 |
| Reactivity: | Human |
| Applications: | Western blotting, Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC59959 |
| Reactivity: | Human |
| Tested Applications: | WB, FC, ELISA |
| Key Applications: | Western blotting, Flow Cytometry |
| Recommended Dilution: | WB 1:1000-1:5000, FC 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | SH-SY5Y, U-87MG |
| Cellular Location: | Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein |
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-530 of human CD140b/PDGFRB(NP_002600.1). |
| Sequence: | LVVTP PGPEL VLNVS STFVL TCSGS APVVW ERMSQ EPPQE MAKAQ DGTFS SVLTL TNLTG LDTGE YFCTH NDSRG LETDE RKRLY IFVPD PTVGF LPNDA EELFI FLTEI TEITI PCRVT DPQLV VTLHE KKGDV ALPVP YDHQR GFSGI FEDRS YICKT TIGDR EVDSD AYYVY RLQVS SINVS VNAVQ TVVRQ GENIT LMCIV IGNEV VNFEW TYPRK ESGRL VEPVT DFLLD MPYHI RSILH IPSAE LEDSG TYTCN VTESV NDHQD EKAIN ITVVE SGYVR LLGEV GTLQF AELHR SRTLQ VVFEA YPPPT VLWFK DNRTL GDSSA GEIAL STRNV SETRY VSELT LVRVK VAEAG HYTMR AFHED AEVQL SFQLQ INVPV RVLEL SESHP DSGEQ TVRCR GRGMP QPNII WSACR DLKRC PRELP PTLLG NSSEE ESQLE TNVTY WEEEQ EFEVV STLRL QHVDR PLSVR CTLRN AVGQD TQEVI VVPHS LPF |
| Synonyms: | PDGFRB, CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT, platelet-derived growth factor receptor beta |
| Calculated MW: | 37kDa/123kDa |
| Observed MW: | 190kDa |
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