CD11b monoclonal antibody (FITC) (AGIM0308)

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SKU:
AGIM0308
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HI11b
Conjugation:
FITC
Applications:
FC

Description

system_update_altDatasheet
Product Name:CD11b monoclonal antibody (FITC)
Product Code:AGIM0308
Size:100 µL
Reactivity:Human
Clone:HI11b
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P11215
Background:CD11b (integrin ?±M subunit) is a 165 kDa type I transmembrane glycoprotein that non-covalently associates with integrin ??2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
UniProt Protein Function:ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.
UniProt Protein Details:

Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; plasma membrane; integrin complex; nucleus; external side of plasma membrane

Molecular Function:heparan sulfate proteoglycan binding; heparin binding; protein binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding

Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; leukocyte migration; toll-like receptor 4 signaling pathway

Disease: Systemic Lupus Erythematosus, Susceptibility To, 6

NCBI Summary:This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Code:P11215
NCBI GenInfo Identifier:1708572
NCBI Gene ID:3684
NCBI Accession:P11215.2
UniProt Secondary Accession:P11215,Q4VAK0, Q4VAK1, Q4VAK2,
UniProt Related Accession:P11215
Molecular Weight:1152
NCBI Full Name:Integrin alpha-M
NCBI Synonym Full Names:integrin, alpha M (complement component 3 receptor 3 subunit)
NCBI Official Symbol:ITGAM  
NCBI Official Synonym Symbols:CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6  
NCBI Protein Information:integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit
UniProt Protein Name:Integrin alpha-M
UniProt Synonym Protein Names:CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD_antigen: CD11b
Protein Family:Integrin
UniProt Gene Name:ITGAM  
UniProt Entry Name:ITAM_HUMAN
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