Name: CD107a monoclonal antibody (AGIM0079)
SKU: AGIM0079
Availability: OutOfStock

CD107a monoclonal antibody (AGIM0079)

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SKU:

AGIM0079

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

H4A3

Conjugation:

Unconjugated

Applications:

Description
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Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Store at 2 ° - 8°C. Do not freeze
Uniprot:	P11279
Background:	CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.

UniProt Protein Function:	LAMP1: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Belongs to the LAMP family.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 13q34 Cellular Component: integral to plasma membrane; lysosome; dendrite; multivesicular body; cell soma; membrane; late endosome; cytoplasm; plasma membrane; melanosome; endosome membrane; sarcolemma; external side of plasma membrane Molecular Function:protein domain specific binding; protein binding; enzyme binding Biological Process: positive regulation of natural killer cell degranulation; induction of apoptosis by granzyme; protein stabilization; viral reproduction; autophagic cell death; autophagy; positive regulation of natural killer cell mediated cytotoxicity
NCBI Summary:	The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
UniProt Code:	P11279
NCBI GenInfo Identifier:	206729915
NCBI Gene ID:	3916
NCBI Accession:	P11279.3
UniProt Secondary Accession:	P11279,Q8WU33, Q96I40, Q9BRD2, Q9NP13, B4DWL3,
UniProt Related Accession:	P11279
Molecular Weight:	417
NCBI Full Name:	Lysosome-associated membrane glycoprotein 1
NCBI Synonym Full Names:	lysosomal-associated membrane protein 1
NCBI Official Symbol:	LAMP1
NCBI Official Synonym Symbols:	LAMPA; CD107a; LGP120
NCBI Protein Information:	lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1
UniProt Protein Name:	Lysosome-associated membrane glycoprotein 1
UniProt Synonym Protein Names:	CD107 antigen-like family member A; CD_antigen: CD107a
Protein Family:	Lysosome-associated membrane glycoprotein
UniProt Gene Name:	LAMP1
UniProt Entry Name:	LAMP1_HUMAN